Dr. Enrique Martín-Gayo, PhD, is group leader who directs basic and translational immunology research at the Immunology Unit of the La Princesa Hospital at the Universidad Autónoma de Madrid.
He has been working in the field of immunology and HIV immunopathogenesis for more than a decade and his group has focused on studying how innate and adaptive immune responses are interconnected and regulated in the context of infectious and autoimmune disorders. His previous work focused on how functional plasticity of dendritic cells (DC) can actively play a role in the regulation of the immune system in the context of tolerance to self and infectious diseases.
Dr. Martín-Gayo obtained his Ph.D degree in 2010 at the Centro de Biologia Molecular Severo Ochoa under the mentorship of Dr. Maria Luisa Toribio where he studied the tolerogenic role of human DCs inducing T regulatory cells (Treg) and identified the physiologic progenitors of human nTreg in the thymus (Martin-Gayo et al, 2010). He was also involved in studying the regulation of thymic progenitors by Notch signaling, focusing on precursors of DC (Martin-Gayo et al, JEM 2017). He also actively participated in several collaborations within and outside the lab that produced 4 additional publications in top scientific journals. During his postdoctoral period at Harvard in Dr. Xu Yu’s laboratory, he studied the contribution of dendritic cells to natural immune control of HIV-1 infection.
His studies specifically analyzed the role of LILR receptors in the context of HIV-1 infection (Martin-Gayo et al, 2014), innate immune sensing of HIV-1 by primary cDCs (Martin-Gayo et al, 2015, Genome Biology 2018) and the ability of DCs to prime T follicular helper cells (Martin-Gayo et al, JCI Insight 2017) in HIV-1 controllers. In addition to his publications, Dr. Martín-Gayo has participated in and presented his work at several national and international scientific meetings like AIDS VACCINE 2013, HIV Research for Prevention 2014 and 2018, Conference on Retroviruses and Opportunistic Infections (CROI) 2016 and 2018.
Additionally, he has been invited to give seminars at the Annual Collaboration for AIDS Vaccine Discovery meeting 2015 and 2018 in Seattle, Washington, USA, wining the Early Career Investigator Award. Similarly, he was recently invited to the annual meeting of the Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery to present his research on DC and Tfh cell priming, given the relevance of his work for vaccine design. For his work, he has received competitive funding from national and international institutions, including National Institutes of Health, the Spanish Ministry of Science (RETOS program), Government of Madrid and the GILEAD grant program. Finally, Dr. Martín-Gayo has been invited to participate in the review scientific articles for several journals from the field as an external reviewer.